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STAT3

维基百科,自由的百科全书
Signal transducer and activator of transcription 3 (acute-phase response factor)
信号转导及转录激活蛋白3(急性期反应因子)
PDB rendering based on 1bg1.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 STAT3; APRF; HIES
扩展标识 遗传学102582 鼠基因103038 同源基因7960 ChEMBL: 4026 GeneCards: STAT3 Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 6774 20848
Ensembl ENSG00000168610 ENSMUSG00000004040
UniProt P40763 P42227
mRNA序列 NM_003150 NM_011486
蛋白序列 NP_003141 NP_035616
基因位置 Chr 17:
40.47 – 40.54 Mb
Chr 11:
100.89 – 100.94 Mb
PubMed查询 [1] [2]

信号转导及转录激活蛋白3(英语:Signal transducer and activator of transcription 3STAT3)是一种由人类基因STAT3 编码的转录因子[1]

功能

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STAT3是STAT蛋白家族的成员。受到细胞因子生长因子的调节,STAT3被受体相关的Janus激酶(JAK)磷酸化,形成同源或异源二聚体,并转移到细胞核,在那里它们起转录激活剂的作用。具体而言,干扰素表皮生长因子(EGF),白细胞介素IL-5IL-6)等配体作用于受体,导致酪氨酸705磷酸化后,STAT3被激活。此外,STAT3可能通过丝裂原活化蛋白激酶(MAPK)[2]c-src非受体酪氨酸激酶磷酸化丝氨酸727而激活。[3][4]STAT3介导响应细胞刺激的各种基因的表达,因此在许多细胞过程如细胞生长和细胞凋亡中起关键作用。[5]

当原肠胚形成开始时,STAT3缺陷的小鼠胚胎不能在胚胎发育第7天以后发育。[6]看来在这些发育的早期阶段,STAT3激活是胚胎干细胞(ESC)自我更新所必需的。事实上,如果STAT3通过其他方式被激活,LIF可以被省略,该LIF被提供给小鼠ESC培养物以保持其未分化状态。[7]

STAT3对于TH17辅助性T细胞的分化至关重要,TH17辅助性T细胞已涉及多种自体免疫性疾病。[8]在病毒感染期间,缺乏T细胞中STAT3的小鼠显示产生T-滤泡辅助(Tfh)细胞的能力受损,并且不能维持基于抗体的免疫性。[9]

临床意义

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在癌症中的双重作用

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相互作用

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STAT3能与下列蛋白质发生交互作用

参考文献

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延伸阅读

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外部链接

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