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ZEB1

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ZEB1
Protein ZEB1 PDB 2e19.png
已知的結構
PDBOrtholog search: PDBe RCSB
識別號
別名ZEB1;AREB6、​BZP、​DELTAEF1、​FECD6、​NIL2A、​PPCD3、​TCF8、​ZFHEP、​ZFHX1A、​zinc finger E-box binding homeobox 1
外部IDMGI1344313 HomoloGene31779 GeneCardsZEB1
RNA表現模式
PBB GE ZEB1 210875 s at fs.png

PBB GE ZEB1 212758 s at fs.png

PBB GE ZEB1 212764 at fs.png
更多參考(基因)表現資料
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_001128128、NM_001174093、NM_001174094、NM_001174095、NM_001174096、NM_030751、XM_006717498、XM_011519643、NM_001323638、NM_001323641、NM_001323642、NM_001323643、NM_001323644、NM_001323645、NM_001323646、NM_001323647、NM_001323648、NM_001323649、NM_001323650、NM_001323651、NM_001323652、NM_001323653、NM_001323654、NM_001323655、NM_001323656、NM_001323657、NM_001323658、NM_001323659、NM_001323660、NM_001323661、NM_001323662、NM_001323663、NM_001323664、NM_001323665、NM_001323666、NM_001323671、NM_001323672、NM_001323673、NM_001323674、NM_001323675、NM_001323676、NM_001323677、NM_001323678、XM_017016597

NM_011546、XM_006525769、XM_006525772、XM_006525775、XM_017317864、NM_001360981、NM_001360982

蛋白序列

NP_001121600、NP_001167564、NP_001167565、NP_001167566、NP_001167567、NP_001310567、NP_001310570、NP_001310571、NP_001310572、NP_001310573、NP_001310574、NP_001310575、NP_001310576、NP_001310577、NP_001310578、NP_001310579、NP_001310580、NP_001310581、NP_001310582、NP_001310583、NP_001310584、NP_001310585、NP_001310586、NP_001310587、NP_001310588、NP_001310589、NP_001310590、NP_001310591、NP_001310592、NP_001310593、NP_001310594、NP_001310595、NP_001310600、NP_001310601、NP_001310602、NP_001310603、NP_001310604、NP_001310605、NP_001310606、NP_001310607、NP_110378、XP_006717561、XP_011517945、XP_016872086

NP_035676、XP_006525832、XP_006525835、XP_006525838、XP_017173353、NP_001347910、NP_001347911

基因位置​(UCSC)Chr 10: 31.32 – 31.53 Mbn/a
PubMed​查找[1][2]
維基資料
檢視/編輯 人類檢視/編輯 小鼠

鋅指結構E-box-結合同源框1(Zinc finger E-box-binding homeobox 1)是一個由人類基因ZEB1編碼的蛋白質[3][4][5]

ZEB1(以前稱為TCF8)編碼一種帶有鋅指結構域和同源框結構域的轉錄因子,結合位點為白血球介素-2基因轉錄起始位點上游100個bp處,通過負調控來抑制白介2的表現。[6]。ZEB1和其哺乳動物中的旁系同源蛋白ZEB2都屬於同源框轉錄因子家族中的鋅指結構家族中的Zeb家族。ZEB1蛋白質有7個鋅指結構和1個同源框結構[7],見右側圖。

臨床意義[編輯]

基因突變對基因與 後多形角膜營養不良3. 最近的一項研究建議其作出貢獻的作用,在 肺癌 的侵襲和轉移的發展。[8]

參考文獻[編輯]

  1. ^ Human PubMed Reference:. 
  2. ^ Mouse PubMed Reference:. 
  3. ^ The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. Genomics. September 1992, 14 (1): 194–6. PMID 1427828. doi:10.1016/S0888-7543(05)80307-6. 
  4. ^ Identification of a zinc finger protein that inhibits IL-2 gene expression. Science. December 1991, 254 (5039): 1791–4. PMID 1840704. doi:10.1126/science.1840704. 
  5. ^ Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1. 
  6. ^ Identification of a zinc finger protein that inhibits IL-2 gene expression. Science. December 1991, 254 (5039): 1791–4. PMID 1840704. doi:10.1126/science.1840704. 
  7. ^ Homeodomain proteins: an update. Chromosoma. July 2016, 125 (3): 497–521. PMC 4901127. PMID 26464018. doi:10.1007/s00412-015-0543-8. 
  8. ^ Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1. Laboratory Investigation; A Journal of Technical Methods and Pathology. April 2014, 94 (4): 362–70. PMID 24468793. doi:10.1038/labinvest.2013.153. 

外部連結[編輯]