丝裂霉素C
外观
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临床资料 | |
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商品名 | Mitosol, Mutamycin, Jelmyto |
其他名称 | UGN-101 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682415 |
核准状况 | |
怀孕分级 | |
给药途径 | 静脉注射、外用 |
药物类别 | 抗肿瘤药 |
ATC码 | |
法律规范状态 | |
法律规范 |
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药物动力学数据 | |
药物代谢 | 肝脏 |
生物半衰期 | 8–48 min |
识别信息 | |
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CAS号 | 50-07-7 |
PubChem CID | |
PubChem SID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.008 |
化学信息 | |
化学式 | C15H18N4O5 |
摩尔质量 | 334.33 g·mol−1 |
3D模型(JSmol) | |
熔点 | 360 °C(680 °F) |
水溶性 | 8.43 g L−1 |
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丝裂霉素C(英语:Mitomycin C)是化疗药物丝裂霉素的一种,分子式C15H18N4O5,1950年代由日本科学家在链霉菌属的Streptomyces caespitosus中发现[5]。
参考文献
[编辑]- ^ Reiss, G.J. KUWQIF: Mitomycin C Dihydrate, also known as (6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate dihydrate. Cambridge Structural Database: Access Structures (Cambridge Crystallographic Data Centre). 2011 [2021-11-03]. doi:10.5517/ccdc.csd.cc12bt29. (原始内容存档于19 November 2021).
- ^ Mitomycin (Mutamycin) Use During Pregnancy. Drugs.com. 19 August 2019 [15 April 2020]. (原始内容存档于22 October 2020).
- ^ Mitocin mitomycin 20 mg powder for injection vial (370360). Therapeutic Goods Administration (TGA). 12 August 2022 [29 April 2023]. (原始内容存档于18 March 2023).
- ^ Mitocin (Echo Therapeutics Pty Ltd). Therapeutic Goods Administration (TGA). 28 September 2022 [29 April 2023]. (原始内容存档于18 March 2023).
- ^ Tomasz M. Mitomycin C: small, fast and deadly (but very selective). Chemistry & Biology. September 1995, 2 (9): 575–579. PMID 9383461. doi:10.1016/1074-5521(95)90120-5
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外部链接
[编辑]- Clinical trial number NCT02793128 for "The OLYMPUS Study - Optimized DeLivery of Mitomycin for Primary UTUC Study (Olympus)" at ClinicalTrials.gov
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