孕酮受体：修订间差异

現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要

Progesterone receptor, N-terminal
鑑定
標誌	Progest_rcpt_N
Pfam	PF02161（旧版）
InterPro（英语：InterPro）	IPR000128
現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要

Progesterone receptor; 孕酮受体
	PDB rendering based on 1a28.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU
标识
代号	PGR; NR3C3; PR
扩展标识	遗传学：607311 鼠基因：97567 同源基因：713 IUPHAR: ChEMBL: 208 GeneCards: PGR Gene
基因本体论描述
分子功能	· DNA binding; · steroid hormone receptor activity; · ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; · receptor binding; · steroid binding; · protein binding; · zinc ion binding; · enzyme binding; · sequence-specific DNA binding;
细胞成分	· nucleus; · nucleoplasm; · nucleolus; · cytoplasm; · intracellular membrane-bounded organelle;
生物过程	· ovulation from ovarian follicle; · epithelial cell maturation; · transcription initiation from RNA polymerase II promoter; · signal transduction; · cell-cell signaling; · gene expression; · negative regulation of gene expression; · regulation of epithelial cell proliferation; · progesterone receptor signaling pathway; · tertiary branching involved in mammary gland duct morphogenesis;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
	查; 论; 编;

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2014年6月28日 (六) 15:15的版本

孕酮受体（英語：progesterone receptor，缩写PR，也被称为NR3C3 ，nuclear receptor subfamily 3, group C, member 3，即核受体第三亚族C组成员3）是一种细胞内蛋白质，由甾体激素孕酮激活。

In humans, PR is encoded by a single PGR gene residing on chromosome 11q22,^[1]^[2]^[3] it has two main forms, A and B, that differ in their molecular weight.^[4]^[5]^[6]

功能

Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration.

After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins.

结构

In common with other steroid receptors, the progesterone receptor has a N-terminal regulatory domain, a DNA binding domain, a hinge section, and a C-terminal ligand binding domain. A special transcription activation function (TAF), called TAF-3, is present in the progesterone receptor-B, in a B-upstream segment (BUS) at the amino acid terminal. This segment is not present in the receptor-A.

互作

孕酮受体has been shown to interact with:

KLF9,^[7]
Nuclear receptor co-repressor 2,^[8] and
UBE3A.^[9]

另见

Selective progesterone receptor modulator

参考文献

^ Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E. Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. Biochem. Biophys. Res. Commun. March 1987, 143 (2): 740–8. PMID 3551956. doi:10.1016/0006-291X(87)91416-1.
^ Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW. The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2. Proc. Natl. Acad. Sci. U.S.A. May 1987, 84 (9): 2877–81. PMC 304763 . PMID 3472240. doi:10.1073/pnas.84.9.2877.
^ ensembl.org, Gene: ESR1 (ENSG00000091831)
^ Gadkar-Sable S, Shah C, Rosario G, Sachdeva G, Puri C. Progesterone receptors: various forms and functions in reproductive tissues. Front. Biosci. 2005, 10: 2118–30. PMID 15970482. doi:10.2741/1685.
^ Kase, Nathan G.; Speroff, Leon; Glass, Robert L. Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. 1999. ISBN 0-683-30379-1.
^ Fritz, Marc A.; Speroff, Leon. Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. 2005. ISBN 0-7817-4795-3.
^ Zhang XL, Zhang D, Michel FJ, Blum JL, Simmen FA, Simmen RC. Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells. J. Biol. Chem. June 2003, 278 (24): 21474–82. PMID 12672823. doi:10.1074/jbc.M212098200.
^ Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP. The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol. Cell. Biol. May 2000, 20 (9): 3102–15. PMC 85605 . PMID 10757795. doi:10.1128/MCB.20.9.3102-3115.2000.
^ Nawaz Z, Lonard DM, Smith CL, Lev-Lehman E, Tsai SY, Tsai MJ, O'Malley BW. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol. Cell. Biol. February 1999, 19 (2): 1182–9. PMC 116047 . PMID 9891052.

延伸阅读

Butnor KJ, Burchette JL, Robboy SJ. Progesterone receptor activity in leiomyomatosis peritonealis disseminata. Int. J. Gynecol. Pathol. 2002, 18 (3): 259–64. PMID 12090595. doi:10.1097/00004347-199907000-00012.
Leonhardt SA, Boonyaratanakornkit V, Edwards DP. Progesterone receptor transcription and non-transcription signaling mechanisms. Steroids. 2004, 68 (10–13): 761–70. PMID 14667966. doi:10.1016/S0039-128X(03)00129-6.
Conneely OM, Mulac-Jericevic B, Lydon JP. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids. 2004, 68 (10–13): 771–8. PMID 14667967. doi:10.1016/S0039-128X(03)00126-0.
Bagchi MK, Tsai SY, Tsai MJ, O'Malley BW. Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (7): 2664–8. PMC 48722 . PMID 1557371. doi:10.1073/pnas.89.7.2664.
Kastner P, Krust A, Turcotte B; et al. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 1990, 9 (5): 1603–14. PMC 551856 . PMID 2328727.
Guiochon-Mantel A, Loosfelt H, Lescop P; et al. Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers. Cell. 1989, 57 (7): 1147–54. PMID 2736623. doi:10.1016/0092-8674(89)90052-4.
Fernandez MD, Carter GD, Palmer TN. The interaction of canrenone with oestrogen and progesterone receptors in human uterine cytosol. British Journal of Clinical Pharmacology. 1983, 15 (1): 95–101. PMC 1427833 . PMID 6849751. doi:10.1111/j.1365-2125.1983.tb01470.x.
Oñate SA, Tsai SY, Tsai MJ, O'Malley BW. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science. 1995, 270 (5240): 1354–7. PMID 7481822. doi:10.1126/science.270.5240.1354.
Zhang Y, Beck CA, Poletti A; et al. Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II. J. Biol. Chem. 1995, 269 (49): 31034–40. PMID 7983041.
Mansour I, Reznikoff-Etievant MF, Netter A. No evidence for the expression of the progesterone receptor on peripheral blood lymphocytes during pregnancy. Hum. Reprod. 1995, 9 (8): 1546–9. PMID 7989520.
Kalkhoven E, Wissink S, van der Saag PT, van der Burg B. Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptor. J. Biol. Chem. 1996, 271 (11): 6217–24. PMID 8626413. doi:10.1074/jbc.271.11.6217.
Wang JD, Zhu JB, Fu Y; et al. Progesterone receptor immunoreactivity at the maternofetal interface of first trimester pregnancy: a study of the trophoblast population. Hum. Reprod. 1996, 11 (2): 413–9. PMID 8671234. doi:10.1093/humrep/11.2.413.
Thénot S, Henriquet C, Rochefort H, Cavaillès V. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. J. Biol. Chem. 1997, 272 (18): 12062–8. PMID 9115274. doi:10.1074/jbc.272.18.12062.
Jenster G, Spencer TE, Burcin MM; et al. Steroid receptor induction of gene transcription: a two-step model. Proc. Natl. Acad. Sci. U.S.A. 1997, 94 (15): 7879–84. PMC 21523 . PMID 9223281. doi:10.1073/pnas.94.15.7879.
Shanker YG, Sharma SC, Rao AJ. Expression of progesterone receptor mRNA in the first trimester human placenta. Biochem. Mol. Biol. Int. 1997, 42 (6): 1235–40. PMID 9305541.
Richer JK, Lange CA, Wierman AM; et al. Progesterone receptor variants found in breast cells repress transcription by wild-type receptors. Breast Cancer Res. Treat. 1998, 48 (3): 231–41. PMID 9598870. doi:10.1023/A:1005941117247.
Williams SP, Sigler PB. Atomic structure of progesterone complexed with its receptor. Nature. 1998, 393 (6683): 392–6. PMID 9620806. doi:10.1038/30775.
Boonyaratanakornkit V, Melvin V, Prendergast P; et al. High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells. Mol. Cell. Biol. 1998, 18 (8): 4471–87. PMC 109033 . PMID 9671457.
Nawaz Z, Lonard DM, Smith CL; et al. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol. Cell. Biol. 1999, 19 (2): 1182–9. PMC 116047 . PMID 9891052.

外部链接

醫學主題詞表（MeSH）：Progesterone+Receptors

此条目包含有源于Pfam以及InterPro的属于公有领域的文本 IPR000342

[pmid3551956-1] Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E. Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. Biochem. Biophys. Res. Commun. March 1987, 143 (2): 740–8. PMID 3551956. doi:10.1016/0006-291X(87)91416-1.

[pmid3472240-2] Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW. The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2. Proc. Natl. Acad. Sci. U.S.A. May 1987, 84 (9): 2877–81. PMC 304763 . PMID 3472240. doi:10.1073/pnas.84.9.2877.

[3] sembl.org, Gene: ESR1 (ENSG00000091831)

[pmid15970482-4] Gadkar-Sable S, Shah C, Rosario G, Sachdeva G, Puri C. Progesterone receptors: various forms and functions in reproductive tissues. Front. Biosci. 2005, 10: 2118–30. PMID 15970482. doi:10.2741/1685.

[isbn0-683-30379-1-5] Kase, Nathan G.; Speroff, Leon; Glass, Robert L. Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. 1999. ISBN 0-683-30379-1.

[isbn0-7817-4795-3-6] Fritz, Marc A.; Speroff, Leon. Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. 2005. ISBN 0-7817-4795-3.

[pmid12672823-7] Zhang XL, Zhang D, Michel FJ, Blum JL, Simmen FA, Simmen RC. Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells. J. Biol. Chem. June 2003, 278 (24): 21474–82. PMID 12672823. doi:10.1074/jbc.M212098200.

[pmid10757795-8] Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP. The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol. Cell. Biol. May 2000, 20 (9): 3102–15. PMC 85605 . PMID 10757795. doi:10.1128/MCB.20.9.3102-3115.2000.

[pmid9891052-9] Nawaz Z, Lonard DM, Smith CL, Lev-Lehman E, Tsai SY, Tsai MJ, O'Malley BW. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol. Cell. Biol. February 1999, 19 (2): 1182–9. PMC 116047 . PMID 9891052.

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