组氨酸脱羧酶

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组氨酸脱羧酶
Histidine decarboxylase.svg
在组氨酸脱羧酶作用下从組氨酸組織胺的转化
识别码
EC编号 4.1.1.22
CAS号 9024-61-7
数据库
IntEnz IntEnz浏览
BRENDA BRENDA入口
ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc 代谢路径
PRIAM 概述
PDB RCSB PDB PDBe PDBsum
基因本体 AmiGO / EGO
组氨酸脱羧酶
标识
代号 HDC; MGC163399
扩展标识 遗传学142704 鼠基因96062 同源基因20490 GeneCards: HDC Gene
EC編號 4.1.1.22
直系同源体
物种 人类 小鼠
Entrez 3067 15186
Ensembl ENSG00000140287 ENSMUSG00000027360
UniProt P19113 P23738
mRNA序列 NM_002112 NM_008230
蛋白序列 NP_002103 NP_032256
基因位置 Chr 15:
48.32 – 48.35 Mb
Chr 2:
126.42 – 126.44 Mb
PubMed查询 [1] [2]

组氨酸脱羧酶英语Histidine decarboxylaseHDC)是一种以如下方式在维生素B6的帮助下催化从組氨酸生成組織胺的反应的[1][2][3]

C6H9N3O2C5H9N3 + CO2

在人体中,组氨酸脱羧酶由HDC基因编码。[4][5]

生物胺组织胺在许多生理过程中有重要的调节作用,包括神经传递、胃酸分泌、平滑肌舒张。从组氨酸到组织胺的生物合成由L-组氨酸脱羧酶催化。这个同源二聚体酶是一个依赖磷酸吡哆醛(PLP)的脱羧酶,并对其底物组氨酸有高度特异性。[4]

参考[编辑]

  1. ^ Epps HM. Studies on bacterial amino-acid decarboxylases: 4. l(-)-histidine decarboxylase from Cl. welchii Type A. Biochem. J. 1945, 39 (1): 42–6. PMC 1258146. PMID 16747851. 
  2. ^ Riley WD, Snell EE. Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group. Biochemistry. 1968-10, 7 (10): 3520–8. PMID 5681461. 
  3. ^ Rosenthaler J, Guirard BM, Chang GW, Snell EE. Purification and properties of histidine decarboxylase from Lactobacillus 30a. Proc. Natl. Acad. Sci. U.S.A. 1965-07, 54 (1): 152–8. PMC 285813. PMID 5216347. 
  4. ^ 4.0 4.1 Entrez Gene: histidine decarboxylase. 
  5. ^ Bruneau G, Nguyen VC, Gros F, Bernheim A, Thibault J. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. Hum. Genet. 1992-11, 90 (3): 235–8. PMID 1487235. 

扩展阅读[编辑]

  • Need AC, Keefe RS, Ge D, et al.. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.. Eur. J. Hum. Genet. 2009, 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMID 19156168. 
  • Masini E, Fabbroni V, Giannini L, et al.. Histamine and histidine decarboxylase up-regulation in colorectal cancer: correlation with tumor stage.. Inflamm. Res. 2005,. 54 Suppl 1: S80–1. doi:10.1007/s00011-004-0437-3. PMID 15928846. 
  • Li Z, Liu J, Tang F, et al.. Expression of non-mast cell histidine decarboxylase in tumor-associated microvessels in human esophageal squamous cell carcinomas.. APMIS. 2008, 116 (12): 1034–42. doi:10.1111/j.1600-0463.2008.01048.x. PMID 19133005. 
  • Szafranski K, Schindler S, Taudien S, et al.. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.. Genome Biol. 2007, 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918. 
  • Ai W, Liu Y, Langlois M, Wang TC. Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements.. J. Biol. Chem. 2004, 279 (10): 8684–93. doi:10.1074/jbc.M308278200. PMID 14670968. 
  • Raychowdhury R, Fleming JV, McLaughlin JT, et al.. Identification and characterization of a third gastrin response element (GAS-RE3) in the human histidine decarboxylase gene promoter.. Biochem. Biophys. Res. Commun. 2002, 297 (5): 1089–95. PMID 12372397. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al.. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Sköldberg F, Portela-Gomes GM, Grimelius L, et al.. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells.. J. Clin. Endocrinol. Metab. 2003, 88 (4): 1445–52. PMID 12679420. 
  • Brew O, Lakasing L, Sullivan M. Differential activity of histidine decarboxylase in normal and pre-eclamptic placentae.. Placenta: 585–7. doi:10.1016/j.placenta.2006.05.003. PMID 16822545. 
  • Zhang F, Xiong DH, Wang W, et al.. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women.. Biochem. Biophys. Res. Commun. 2006, 348 (4): 1378–82. doi:10.1016/j.bbrc.2006.08.008. PMID 16919600. 
  • Tippens AS, Gruetter CA. Detection of histidine decarboxylase mRNA in human vascular smooth muscle and endothelial cells.. Inflamm. Res. 2004, 53 (6): 215–6. doi:10.1007/s00011-004-1252-6. PMID 15167966. 
  • Siezen CL, Bont L, Hodemaekers HM, et al.. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.. Pediatr. Infect. Dis. J. 2009, 28 (4): 333–5. doi:10.1097/INF.0b013e31818e2aa9. PMID 19258923. 
  • Morgan TK, Montgomery K, Mason V, et al.. Upregulation of histidine decarboxylase expression in superficial cortical nephrons during pregnancy in mice and women.. Kidney Int. 2006, 70 (2): 306–14. doi:10.1038/sj.ki.5001553. PMID 16760908. 
  • Papadopoulou N, Kalogeromitros D, Staurianeas NG, et al.. Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria.. J. Invest. Dermatol. 2005, 125 (5): 952–5. doi:10.1111/j.0022-202X.2005.23913.x. PMID 16297195. 
  • Janssen R, Bont L, Siezen CL, et al.. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.. J. Infect. Dis. 2007, 196 (6): 826–34. doi:10.1086/520886. PMID 17703412. 
  • Strausberg RL, Feingold EA, Grouse LH, et al.. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Aichberger KJ, Mayerhofer M, Vales A, et al.. The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells.. Blood. 2006, 108 (10): 3538–47. doi:10.1182/blood-2005-12-028456. PMID 16849647. 
  • Lee JK, Kim HT, Cho SM, et al.. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.. J. Hum. Genet. 2003, 48 (5): 213–6. doi:10.1007/s10038-003-0011-9. PMID 12768436. 
  • Jeong HJ, Moon PD, Kim SJ, et al.. Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression.. Cell. Mol. Life Sci. 2009, 66 (7): 1309–19. doi:10.1007/s00018-009-9001-1. PMID 19266161. 

外部链接[编辑]