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孕三烯酮

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孕三烯酮
臨床資料
商品名英語Drug nomenclatureDimetriose, Dimetrose, Nemestran, others
其他名稱Ethylnorgestrienone; A-46745; R2323; R-2323; RU-2323; 17α-Ethynyl-18-methyl-δ9,11-19-nortestosterone; 17α-Ethynyl-18-methylestra-4,9,11-trien-17β-ol-3-one; 13β-Ethyl-18,19-dinor-17α-pregna-4,9,11-trien-20-yn-17β-ol-3-one
AHFS/Drugs.com國際藥品名稱
懷孕分級
  • X
給藥途徑By mouth, vaginal[1]
藥物類別英語Drug classProgestin; Progestogen; Antiprogestogen; Androgen; Anabolic steroid; Steroidogenesis inhibitor; Antiestrogen
ATC碼
藥物動力學數據
血漿蛋白結合率To albumin[1]
藥物代謝Liver (hydroxylation)[1]
生物半衰期27.3 hours[1]
排泄途徑Urine and bile[1]
識別資訊
  • (8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS號16320-04-0  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.210.606 編輯維基數據鏈接
化學資訊
化學式C21H24O2
摩爾質量308.41 g/mol
3D模型(JSmol英語JSmol
  • O=C4\C=C3/C(=C2/C=C\[C@]1([C@@H](CC[C@]1(C#C)O)[C@@H]2CC3)CC)CC4
  • InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1 checkY
  • Key:BJJXHLWLUDYTGC-ANULTFPQSA-N checkY

孕三烯酮(英語:Gestrinone)是一種用於治療子宮內膜異位症的藥物[2][3],也用於治療子宮肌瘤經血過多以及進行生育控制[1]。孕三烯酮通常單獨使用,不與其他藥物聯合使用[4],可由口服給藥陰道內給藥[1]

參考文獻

[編輯]
  1. ^ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Eric J. Thomas; John Rock. Modern Approaches to Endometriosis. Springer Science & Business Media. 6 December 2012: 228, 232, 234. ISBN 978-94-011-3864-2. 
  2. ^ Coutinho EM. Therapeutic experience with gestrinone. Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749. 
  3. ^ Dr. Ian Morton; I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999: 132–. ISBN 978-0-7514-0499-9. 
  4. ^ 引用錯誤:沒有為名為Drugs.com的參考文獻提供內容

延伸閱讀

[編輯]
  • Coutinho E, Gonçalves MT, Azadian-Boulanger G, Silva AR. Endometriosis therapy with gestrinone by oral, vaginal or parenteral administration. Contrib Gynecol Obstet. 1987, 16: 227–35. PMID 3691096. doi:10.1159/000414891 (不活躍 2018-10-13). 
  • Coutinho EM. Therapeutic experience with gestrinone. Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749.