维基百科 中的医学内容
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路易氏体失智症 [存在争议，此翻译无法与 Lewy body dementias 区别] dementia with Lewy bodies ，DLB）属于一种 Lewy body dementias [1] 行为 认知 及活动功能退化 失智症 [2] [3] 随着时间逐渐恶化 [4] 日常生活 ，之后接受检查而确诊[2] [5] 动眼期睡眠行为障碍 动眼期 应出现的肌失张 [2] [6] 幻觉 、注意力 的起伏不定及行动迟缓 、步态不稳或运动功能减退 [2] 影响 ，导致血压 、心脏及消化道功能改变，并且常常便秘 [7] 抑郁 及对人冷漠 等情绪转变也很常见[2]
目前还无法确定路易氏体失智症的确切原因[8] α-突触核蛋白 路易氏体 [9] [10] [8] 生物标记 来判断，诊断会包括血液检查 、神经心理学测试 医学影像 及多项生理睡眠检查 [2] [11] 会有类似症状的疾病 有阿兹海默症 、帕金森氏症 、谵妄 ，偶尔思觉失调 也会有类似症状[3]
目前没有治愈方法或药物会改变疾病的进展[8] [8] [5] [12] [13] 乙酰胆碱酯酶抑制剂 donepezil rivastigmine 褪黑激素 则可用于睡眠相关症状[2] 抗精神病药物 ，因为患者对这类药物很敏感[2] [14] [9]
路易氏体失智症是常见失智症中的一种，另外二种是阿兹海默症 及血管性痴呆 [11] [15] [a] [16] [17] 预期寿命 约8年。[8] Frederic Lewy 小阪宪司 [4]
知名患者 [ 编辑 ]
^ Kosaka (2017) writes: "Dementia with Lewy bodies (DLB) is now well known to be the second most frequent dementia following Alzheimer disease (AD). Of all types of dementia, AD is known to account for about 50%, DLB about 20% and vascular dementia (VD) about 15%. Thus, AD, DLB, and VD are now considered to be the three major dementias."[15] [11]
参考文献 [ 编辑 ]
^ Gomperts SN. Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia . Continuum (Minneap Minn). April 2016, 22 (2 Dementia): 435–63. PMC 5390937 PMID 27042903 doi:10.1212/CON.0000000000000309 ^ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 McKeith, Ian G.; Boeve, Bradley F.; Dickson, Dennis W.; Halliday, Glenda; Taylor, John-Paul; Weintraub, Daniel; Aarsland, Dag; Galvin, James; Attems, Johannes; Ballard, Clive G.; Bayston, Ashley. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium . Neurology. 2017-07-04, 89 (1). ISSN 0028-3878 PMC 5496518 PMID 28592453 doi:10.1212/WNL.0000000000004058 （英语） . ^ 3.0 3.1 Tousi, Babak. Diagnosis and Management of Cognitive and Behavioral Changes in Dementia With Lewy Bodies . Current Treatment Options in Neurology. 2017-10-09, 19 (11). ISSN 1534-3138 doi:10.1007/s11940-017-0478-x （英语） . ^ 4.0 4.1 Weil, Rimona S.; Lashley, Tammaryn L.; Bras, Jose; Schrag, Anette E.; Schott, Jonathan M. Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies . F1000Research. 2017-08-30, 6 [2022-10-15 ] . ISSN 2046-1402 PMC 5580419 PMID 28928962 doi:10.12688/f1000research.11725.1 存档 于2022-07-17） （英语） . ^ 5.0 5.1 Louis, Erik K. St; Boeve, Bradley F. REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions . Mayo Clinic Proceedings. 2017-11-01, 92 (11). ISSN 0025-6196 PMC 6095693 PMID 29101940 doi:10.1016/j.mayocp.2017.09.007 （英语） . ^ St Louis, Erik K.; Boeve, Angelica R.; Boeve, Bradley F. REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies . Movement Disorders: Official Journal of the Movement Disorder Society. 2017-05, 32 (5) [2022-10-15 ] . ISSN 1531-8257 PMID 28513079 doi:10.1002/mds.27018 存档 于2022-10-19）. ^ Palma, Jose-Alberto; Kaufmann, Horacio. Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies . Movement Disorders: Official Journal of the Movement Disorder Society. 2018-03, 33 (3) [2022-10-15 ] . ISSN 1531-8257 PMC 5844369 PMID 29508455 doi:10.1002/mds.27344 存档 于2022-10-16）. ^ 8.0 8.1 8.2 8.3 8.4 Dementia with Lewy bodies information page . National Institute of Neurological Disorders and Stroke. May 25, 2017 [April 7, 2018] . （原始内容存档 于2021-06-10）. ^ 9.0 9.1 Walker, Zuzana; Possin, Katherine L.; Boeve, Bradley F.; Aarsland, Dag. Lewy body dementias . The Lancet. 2015-10-24, 386 (10004). ISSN 0140-6736 PMC 5792067 PMID 26595642 doi:10.1016/S0140-6736(15)00462-6 （英语） . ^ Velayudhan, Latha; Ffytche, Dominic; Ballard, Clive; Aarsland, Dag. New Therapeutic Strategies for Lewy Body Dementias . Current Neurology and Neuroscience Reports. 2017-09, 17 (9). ISSN 1528-4042 doi:10.1007/s11910-017-0778-2 （英语） . ^ 11.0 11.1 11.2 Lewy body dementia: Hope through research . National Institute of Neurological Disorders and Stroke. US National Institutes of Health. December 8, 2017 [April 6, 2018] . （原始内容存档 于2021-04-30）. ^ Mueller, Christoph; Ballard, Clive; Corbett, Anne; Aarsland, Dag. The prognosis of dementia with Lewy bodies . The Lancet Neurology. 2017-05-01, 16 (5). ISSN 1474-4422 PMID 28342649 doi:10.1016/S1474-4422(17)30074-1 （英语） . ^ Boot, Brendon P.; McDade, Eric M.; McGinnis, Scott M.; Boeve, Bradley F. Treatment of Dementia With Lewy Bodies . Current Treatment Options in Neurology. 2013-12, 15 (6). ISSN 1092-8480 PMC 3913181 PMID 24222315 doi:10.1007/s11940-013-0261-6 （英语） . ^ Boot, Brendon P. Comprehensive treatment of dementia with Lewy bodies . Alzheimer's Research & Therapy. 2015-12, 7 (1) [2022-10-15 ] . ISSN 1758-9193 PMC 4448151 PMID 26029267 doi:10.1186/s13195-015-0128-z 存档 于2022-12-05） （英语） . ^ 15.0 15.1 Kosaka K, ed. (2017), p. v.
^ Levin, Johannes; Kurz, Alexander; Arzberger, Thomas; Giese, Armin; Höglinger, Günter U. The Differential Diagnosis and Treatment of Atypical Parkinsonism . Deutsches Ärzteblatt international. 2016-02-05. ISSN 1866-0452 PMC 4782269 PMID 26900156 doi:10.3238/arztebl.2016.0061 ^ What is Lewy body dementia? . National Institute on Aging. US National Institutes of Health. May 17, 2017 [April 7, 2018] . （原始内容存档 于2016-10-06）.
外部连接 [ 编辑 ] 
. PMID 27042903. doi:10.1212/CON.0000000000000309.
