甲萘醌：修订间差异

甲萘醌
	IUPAC名; 2-Methylnaphthalene-1,4-dione
别名	Menaphthone; Vitamin K3; β-Methyl-1,4-naphthoquinone; 2-Methyl-1,4-naphthodione; 2-Methyl-1,4-naphthoquinone
识别
CAS号	58-27-5
PubChem	4055
ChemSpider	3915
SMILES	O=C\2c1c(cccc1)C(=O)/C(=C/2)C;
InChI	1/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3;
InChIKey	MJVAVZPDRWSRRC-UHFFFAOYAY
ChEBI	28869
DrugBank	DB00170
KEGG	D02335
性质
化学式	C11H8O2
摩尔质量	172.18 g·mol−1
外观	Bright yellow crystals
密度	1.225g/cm3
熔点	105 - 107 °C（271 K）
溶解性（水）	不可溶
药理学
ATC代码	B02BA02（B02）
药品分级
妊娠分类	Contraindicated in India
给药途径	Oral; Intravenous; 肌肉注射;
危险性
	致死量或浓度：
LD50（中位剂量）	0.5 g/kg (oral, mouse)
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

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2022年3月9日 (三) 05:05的版本

甲萘醌（英語：Menadione，也称为2-甲基-1,4-萘醌，Menadione，2-Methylnaphthalene-1,4-dione，有时也称作维生素K₃）^[2]是一种化学式为 C₆H₄(CO)₂C₂H(CH₃)的有机化合物，可看作1,4-萘醌在2号为增加了一个甲基的结构类似物^[3]。

参考文献

^ The Merck Index, 11th Edition, 5714
^ Hirota, Yoshihisa; Tsugawa, Naoko; Nakagawa, Kimie; Suhara, Yoshitomo; Tanaka, Kiyoshi; Uchino, Yuri; Takeuchi, Atsuko; Sawada, Natsumi; Kamao, Maya; Wada, Akimori; Okitsu, Takashi. Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. The Journal of Biological Chemistry. 2013-11-15, 288 (46): 33071–33080. ISSN 1083-351X. PMC 3829156 . PMID 24085302. doi:10.1074/jbc.M113.477356 .
^ Castro FA, Mariani D, Panek AD, Eleutherio EC, Pereira MD. Fox , 编. Cytotoxicity mechanism of two naphthoquinones (menadione and plumbagin) in Saccharomyces cerevisiae. PLOS ONE. 2008, 3 (12): e3999. Bibcode:2008PLoSO...3.3999C. PMC 2600608 . PMID 19098979. doi:10.1371/journal.pone.0003999 .

[1] The Merck Index, 11th Edition, 5714

[nat-2] Hirota, Yoshihisa; Tsugawa, Naoko; Nakagawa, Kimie; Suhara, Yoshitomo; Tanaka, Kiyoshi; Uchino, Yuri; Takeuchi, Atsuko; Sawada, Natsumi; Kamao, Maya; Wada, Akimori; Okitsu, Takashi. Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. The Journal of Biological Chemistry. 2013-11-15, 288 (46): 33071–33080. ISSN 1083-351X. PMC 3829156 . PMID 24085302. doi:10.1074/jbc.M113.477356 .

[pmid19098979-3] Castro FA, Mariani D, Panek AD, Eleutherio EC, Pereira MD. Fox , 编. Cytotoxicity mechanism of two naphthoquinones (menadione and plumbagin) in Saccharomyces cerevisiae. PLOS ONE. 2008, 3 (12): e3999. Bibcode:2008PLoSO...3.3999C. PMC 2600608 . PMID 19098979. doi:10.1371/journal.pone.0003999 .

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