氟替卡松

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氟替卡松
Fluticasone.svg
Fluticasone ball-and-stick animation.gif
系统(IUPAC)命名名称
S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-
6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-
6,7,8,11,12,14,15,16-octahydrocyclopenta[a]
phenanthrene-17-carbothioate
临床数据
Drugs.com Monograph
妊娠分级
  • C(鼻腔內吸入)
给药途径 鼻腔內吸入,局部塗搽
合法狀態
合法状态
药代动力学数据
生物利用度 0.51% (鼻腔內)
蛋白结合度 91%
代谢 鼻腔內
肝臟(CYP3A4-中介)
生物半衰期 10小時
排泄 腎臟
识别信息
CAS注册号90566-53-3 ✗
80474-14-2 (丙酸酯)
ATC代码 D07AC17 R01AD08 R03BA05
PubChem CID 5311101
DrugBank DB00588 ✗
ChemSpider 4470631 ✓
UNII CUT2W21N7U ✓
KEGG D07981 ✓
ChEBI CHEBI:5134 ✗
ChEMBL英语ChEMBL CHEMBL1201396 ✗
化学信息
化学式 C22H27F3O4S
摩尔质量 444.508 g/mol
 ✗✓ (what is this?)英语Wikipedia:WikiProject_Chemicals/Chembox_validation  (verify)

氟替卡松(fluticasone)為一種綜合的糖皮质激素[1]

糠酸酯(furoate)或丙酸酯(propanoate)的合成品可以用為局部抗炎性、比如鼻炎方面:[2]

參見[编辑]

註釋[编辑]

  1. ^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J., Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins: 600, 2012, ISBN 1451153597. 
  2. ^ Spratto, George R.; Woods, Adrienne L., Delmar Nurse's Drug Handbook 2012, Cengage Learning: 748, 2012, ISBN 1111310653. 

參考文獻[编辑]

  • Jarvis B., Faulds D. (1999): Inhaled fluticasone propionate: A review of its therapeutic efficacy at dosages < or = 500 microg/day in adults and adolescents with mild to moderate asthma. Drugs, 57(5), 769–803. PMID 10353302
  • Johnson M. (1995): The anti-inflammatory profile of fluticasone propionate. Allergy, 50(23), 11–14. PMID 7604948
  • Keating G.M., McCormack P.L. (2007): Salmeterol/fluticasone propionate: a review of its use in the treatment of chronic obstructive pulmonary disease. Drugs, 67(16), 2383–2405. PMID 17983257
  • Reynolds N.A., Lyseng-Williamson K.A., Wiseman L.R. (2005): Inhaled salmeterol/fluticasone propionate: a review of its use in asthma. Drugs, 65(12), 1715–1734. PMID 16060707
  • Spencer C.M., Jarvis B. (1999): Salmeterol/fluticasone propionate combination. Drugs, 57(6), 933–940. PMID 10400406
  • Staresinic A.G., Sorkness C.A. (2000): Fluticasone propionate: A potent inhaled corticosteroid for the treatment of asthma. Expert Opin Pharmacother, 1(6), 1227-1244. PMID 11249490
  • Avamys, Zusammenfasuung der Merkmale des Arzneimittels (PDF; 440 kB), Stand Dezember 2012, Europäische Arzneimittelagentur.