氟替卡松

氟替卡松
臨床資料
AHFS/Drugs.com	Monograph
懷孕分級	C(鼻腔內吸入);
给药途径	鼻腔內吸入，局部塗搽
ATC碼	D07AC17 (WHO) R01AD08 R03BA05;
法律規範狀態
法律規範	英：处方药（℞-only） (POM); 美：处方药（℞-only）;
藥物動力學數據
生物利用度	0.51% (鼻腔內)
血漿蛋白結合率	91%
药物代谢	鼻腔內; 肝臟(CYP3A4-中介)
生物半衰期	10小時
排泄途徑	腎臟
识别信息
	IUPAC命名法 S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-; 6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-; 6,7,8,11,12,14,15,16-octahydrocyclopenta[a]; phenanthrene-17-carbothioate; ;
CAS号	80474-14-2（（丙酸酯）） ; 90566-53-3
PubChem CID	5311101;
DrugBank	DB00588 ;
ChemSpider	4470631 ;
UNII	CUT2W21N7U;
KEGG	D07981 ;
ChEBI	CHEBI:5134 ;
ChEMBL	ChEMBL1201396 ;
CompTox Dashboard (EPA)	DTXSID0044022 ;
化学信息
化学式	C22H27F3O4S
摩尔质量	444.508 g/mol
3D模型（JSmol）	交互式图像;
	SMILES O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C;
	InChI InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 ; Key:MGNNYOODZCAHBA-GQKYHHCASA-N ;

氟替卡松（INN：fluticasone）為一種局部用，与受体亲和力高，合成的三氟糖皮质激素，有抗炎、抗过敏等作用^[1]^[2]。

氟替卡松常以糠酸酯（furoate）或丙酸酯（propanoate）形式作为制剂，可用作局部抗炎药，治疗皮炎、鼻炎、哮喘等疾病^[3]^[4]：

參見

^ 顾之燕.新一代鼻腔局部应用类固醇药物——丙酸氟替卡松和糠酸莫米松的临床研究[J].中华耳鼻咽喉科杂志, 2002, 37(6):6.DOI:CNKI:SUN:ZHEB.0.2002-06-030.
^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J., Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins: 600, 2012 [2013-10-28], ISBN 1451153597, （原始内容存档于2014-01-01）.
^ Spratto, George R.; Woods, Adrienne L., Delmar Nurse's Drug Handbook 2012, Cengage Learning: 748, 2012 [2013-10-28], ISBN 1111310653, （原始内容存档于2014-01-01）.
^ 王家璧. 皮肤性病治疗与检测进展精要. 清华大学出版社有限公司. 2005: 209. ISBN 9787302117278.

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