膽囊收縮素

Cholecystokinin; 胆囊收缩素
标识
代号	CCK; MGC117187
扩展标识	遗传学：118440 鼠基因：88297 同源基因：583 ChEMBL: 1649050 GeneCards: CCK Gene
基因本体论描述
分子功能	· hormone activity; · neuropeptide hormone activity;
细胞成分	· extracellular region; · extracellular space; · axon; · dendrite; · axon initial segment; · terminal bouton; · axon hillock; · perikaryon;
生物过程	· behavioral fear response; · neuron migration; · release of cytochrome c from mitochondria; · activation of cysteine-type endopeptidase activity involved in apoptotic process; · signal transduction; · protein kinase C-activating G-protein coupled receptor signaling pathway; · axonogenesis; · positive regulation of cell proliferation; · negative regulation of appetite; · positive regulation of protein oligomerization; · eating behavior; · positive regulation of apoptotic process; · positive regulation of peptidyl-tyrosine phosphorylation; · positive regulation of mitochondrial depolarization; · regulation of sensory perception of pain;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
	查; 论; 编;

膽囊收縮素（英語：cholecystokinin，簡稱CCK或CCK-PZ；詞源來自於希臘語的chole，膽汁之意；cysto，囊狀之意；kinin，移動之意；組合起來的意義為「移動膽汁之囊」）是一種消化系統當中的肽類激素，可以促進脂肪與蛋白質的消化。膽囊收縮素在此之前名為促胰酶素（pancreozymin），是由小腸的黏膜上皮細胞當中的I細胞所合成，並由十二指腸分泌；這會導致從胰臟與膽囊，各自釋放消化酶與膽汁。膽囊收縮素也是一種食欲抑制劑。最近的證據暗示，膽囊收縮素在促進鴉片類藥物的藥物容許量，如嗎啡和海洛因，扮演著重要角色，並且在經歷鴉片類藥物停藥後的疼痛過敏經歷有著部份的關聯性^[1]^[2]。

參見

參考文獻

^ Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth. Analg. 2000, 91 (1): 110–6. PMID 10866896. doi:10.1097/00000539-200007000-00021.
^ Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. J. Pharmacol. Sci. 2007, 104 (2): 159–66. PMID 17558184. doi:10.1254/jphs.FP0070475.

外部連結

醫學主題詞表（MeSH）：Cholecystokinin

[pmid10866896-1] Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth. Analg. 2000, 91 (1): 110–6. PMID 10866896. doi:10.1097/00000539-200007000-00021.

[pmid17558184-2] Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. J. Pharmacol. Sci. 2007, 104 (2): 159–66. PMID 17558184. doi:10.1254/jphs.FP0070475.

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