乌美溴铵
外观
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臨床資料 | |
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商品名 | Incruse Ellipta |
其他名稱 | GSK573719A、芜地溴铵 |
核准狀況 | |
给药途径 | 吸入(DPI) |
ATC碼 |
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法律規範狀態 | |
法律規範 |
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藥物動力學數據 | |
血漿蛋白結合率 | ~89%[2] |
药物代谢 | 肝(CYP2D6) |
生物半衰期 | 11 hours |
排泄途徑 | 粪便(58%)和尿液(22%) |
识别信息 | |
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CAS号 | 869113-09-7 |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.166.375 |
化学信息 | |
化学式 | C29H34BrNO2 |
摩尔质量 | 508.50 g·mol−1 |
3D模型(JSmol) | |
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乌美溴铵(INN:umeclidinium bromide;商品名:Incruse Ellipta),或译芜地溴铵,是一种长效毒蕈碱拮抗剂,被批准用于慢性阻塞性肺病(COPD)的维持治疗。[2]它还被批准与维兰特罗(乌美溴铵/维兰特罗)联合用于该适应症[3][4]以及作为糠酸氟替卡松/乌美溴铵/维兰特罗的三重疗法组合。[5]
它被列入世界卫生组织的基本药物清单。[6]2020年,它是美国第245位最常用处方药物,处方数量超过100万张。[7][8]
参考资料
[编辑]- ^ Prescription medicines: registration of new chemical entities in Australia, 2014. Therapeutic Goods Administration (TGA). 21 June 2022 [10 April 2023]. (原始内容存档于2023-04-10).
- ^ 2.0 2.1 Incruse Ellipta (umeclidinium inhalation powder) for Oral Inhalation Use. Full Prescribing Information (PDF). GlaxoSmithKline, Research Triangle Park, NC 27709. [22 February 2016]. (原始内容 (PDF)存档于10 July 2018).
- ^ Feldman GJ, Edin A. The combination of umeclidinium bromide and vilanterol in the management of chronic obstructive pulmonary disease: current evidence and future prospects. Therapeutic Advances in Respiratory Disease. December 2013, 7 (6): 311–9. PMID 24004659. S2CID 5744282. doi:10.1177/1753465813499789.
- ^ FDA Approves Umeclidinium and Vilanterol Combo for COPD. Medscape. December 18, 2013 [2024-03-07]. (原始内容存档于2017-09-24).
- ^ TRELEGY ELLIPTA Package Insert (PDF). GlaxoSmithKline. September 2017 [11 July 2020]. (原始内容存档 (PDF)于2020-07-12).
- ^ World Health Organization. World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. hdl:10665/345533
. WHO/MHP/HPS/EML/2021.02.
- ^ The Top 300 of 2020. ClinCalc. [7 October 2022]. (原始内容存档于2021-02-12).
- ^ Umeclidinium - Drug Usage Statistics. ClinCalc. [7 October 2022]. (原始内容存档于2023-09-24).
外部链接
[编辑]- Umeclidinium. Drug Information Portal. U.S. National Library of Medicine. [2024-03-07]. (原始内容存档于2022-12-01).
- Umeclidinium bromide. Drug Information Portal. U.S. National Library of Medicine. [2024-03-07]. (原始内容存档于2022-06-02).
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