胰岛素样生长因子1：修订间差异

Insulin-like growth factor 1 (somatomedin C); 胰岛素样生长因子1（生长调节素C）
	PDB rendering based on 1bqt.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1B9G, 1BQT, 1GF1, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSP, 2DSQ, 2DSR, 2GF1, 3GF1, 3LRI
标识
代号	IGF1; IGF-I; IGF1A; IGFI
扩展标识	遗传学：147440 鼠基因：96432 同源基因：515 GeneCards: IGF1 Gene
基因本体论描述
分子功能	· insulin receptor binding; · insulin-like growth factor receptor binding; · integrin binding; · hormone activity; · protein binding; · growth factor activity;
细胞成分	· extracellular region; · extracellular space; · plasma membrane; · insulin-like growth factor binding protein complex; · platelet alpha granule lumen;
生物过程	· skeletal system development; · cell activation; · blood vessel remodeling; · platelet degranulation; · DNA replication; · cellular component movement; · signal transduction; · Ras protein signal transduction; · muscle organ development; · blood coagulation; · positive regulation of cell proliferation; · negative regulation of cell proliferation; · glycolate metabolic process; · glial cell differentiation; · positive regulation of cardiac muscle hypertrophy; · positive regulation of phosphatidylinositol 3-kinase signaling; · skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; · muscle hypertrophy; · myotube cell development; · positive regulation of smooth muscle cell migration; · positive regulation of cerebellar granule cell precursor proliferation; · water homeostasis; · proteoglycan biosynthetic process; · platelet activation; · mammary gland development; · exocrine pancreas development; · regulation of establishment or maintenance of cell polarity; · positive regulation of protein import into nucleus, translocation; · negative regulation of smooth muscle cell apoptotic process; · multicellular organism growth; · bone mineralization involved in bone maturation; · regulation of multicellular organism growth; · positive regulation of activated T cell proliferation; · positive regulation of tyrosine phosphorylation of Stat5 protein; · positive regulation of DNA binding; · positive regulation of MAPK cascade; · positive regulation of insulin-like growth factor receptor signaling pathway; · cellular protein metabolic process; · myoblast differentiation; · positive regulation of osteoblast differentiation; · positive regulation of glycogen biosynthetic process; · positive regulation of DNA replication; · positive regulation of glycolytic process; · positive regulation of mitosis; · positive regulation of transcription, DNA-templated; · positive regulation of transcription from RNA polymerase II promoter; · positive regulation of glucose import; · positive regulation of Ras protein signal transduction; · insulin-like growth factor receptor signaling pathway; · phosphatidylinositol-mediated signaling; · positive regulation of fibroblast proliferation; · lung alveolus development; · positive regulation of smooth muscle cell proliferation; · branching morphogenesis of an epithelial tube; · inner ear development; · chondroitin sulfate proteoglycan biosynthetic process; · positive regulation of epithelial cell proliferation; · positive regulation of peptidyl-tyrosine phosphorylation; · myoblast proliferation; · positive regulation of protein kinase B signaling; · lung vasculature development; · lung lobe morphogenesis; · Type I pneumocyte differentiation; · Type II pneumocyte differentiation; · prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; · prostate gland growth; · prostate gland stromal morphogenesis; · negative regulation of androgen receptor signaling pathway; · negative regulation of ERK1 and ERK2 cascade; · positive regulation of calcineurin-NFAT signaling cascade; · negative regulation of release of cytochrome c from mitochondria; · extrinsic apoptotic signaling pathway in absence of ligand; · positive regulation of myoblast proliferation; · negative regulation of extrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
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2015年2月5日 (四) 15:12的版本

胰岛素样生长因子1（{{lang-en|Insulin-like growth factor 1，IGF-1）也被称为生长调节素Csomatomedin C，是一个由人类基因 IGF1 编码的蛋白质^[1]^[2]。在1970年代，IGF-1也曾经被称为“酸硫化（英语：sulfation）因子”^[3]，其作用为“不受抑制的胰岛样活力”（nonsuppressible insulin-like activity，NSILA）。

IGF-1是一个在三级结构上与胰岛素类似的激素，在儿童成长发育中有重要作用，并持续在成人的合成代谢中起作用。一种人工合成的IGF-1类似物，美卡舍明（英语：mecasermin），用于治疗发育停滞。^[4]

IGF-1蛋白由一个肽链构成，包括70个氨基酸残基和三个分子内二硫键，分子量为7,649道尔顿。^[5]

参考文献

^ Höppener, JW; de Pagter-Holthuizen, P; Geurts van Kessel, AH; Jansen, M; Kittur, SD; Antonarakis, SE; et al. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Jansen, M; van Schaik, FM; Ricker, AT; Bullock, B; Woods, DE; Gabbay, KH; et al. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Salmon, WD; Daughaday, WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^ Keating, GM. Mecasermin. BioDrugs. 2008, 22 (3): 177–88. PMID 18481900. doi:10.2165/00063030-200822030-00004. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^ Rinderknecht, E; Humbel, RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

延伸阅读

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外部链接

醫學主題詞表（MeSH）：Insulin-Like+Growth+Factor+I
IGF-1 at Lab Tests Online
IGF-1 recombinant GFP labeled at Protean Ltd.

[pmid2982726-1] Höppener, JW; de Pagter-Holthuizen, P; Geurts van Kessel, AH; Jansen, M; Kittur, SD; Antonarakis, SE; et al. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid6358902-2] Jansen, M; van Schaik, FM; Ricker, AT; Bullock, B; Woods, DE; Gabbay, KH; et al. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[3] Salmon, WD; Daughaday, WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid18481900-4] Keating, GM. Mecasermin. BioDrugs. 2008, 22 (3): 177–88. PMID 18481900. doi:10.2165/00063030-200822030-00004. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid632300-5] Rinderknecht, E; Humbel, RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

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