环氯唑仑

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环氯唑仑
Ball-and-stick model of the ciclotizolam molecule
臨床資料
ATC碼
  • 未分配
法律規範狀態
法律規範
识别信息
  • 8-bromo-6-(o-chlorophenyl)-1-cyclohexyl-4H-5-triazolo(3,4-c)thieno(2,4-e)-1,4-diazepine
CAS号58765-21-2  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
化学信息
化学式C20H18BrClN4S
摩尔质量461.81 g·mol−1
3D模型(JSmol英语JSmol
  • Clc5ccccc5C/2=N/Cc1nnc(n1c3sc(Br)cc\23)C4CCCCC4
  • InChI=1S/C20H18BrClN4S/c21-16-10-14-18(13-8-4-5-9-15(13)22)23-11-17-24-25-19(26(17)20(14)27-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7,11H2 checkY
  • Key:ZOSHXIXUCKESEG-UHFFFAOYSA-N checkY

环氯唑仑英语:Ciclotizolam[1] ,代号:WE-973) 是一种噻吩并三唑并二氮䓬衍生药物。它是GABAA受体苯二氮䓬位点的部分激动剂,与溴替唑仑等相关化合物具有相似的结合亲和力,但疗效较低。[2][3]

参见[编辑]

参考资料[编辑]

  1. ^ DE Patent 2445430
  2. ^ Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P. Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines'). European Journal of Pharmacology. February 1985, 109 (1): 19–31. PMID 2986988. doi:10.1016/0014-2999(85)90535-7. 
  3. ^ Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI. Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles. Life Sciences. 1989, 45 (4): 349–58. PMID 2569655. doi:10.1016/0024-3205(89)90145-8.