依法西泮
 | |
| 临床资料 | |
|---|---|
| ATC码 |
|
| 识别信息 | |
| |
| CAS号 | 52042-01-0  |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C19H18ClFN2O3S |
| 摩尔质量 | 408.87 |
| 3D模型（JSmol） | |
| |
| |
依法西泮（英语：Elfazepam[1]）是一种药物，是苯二氮䓬类衍生物。[2]据推测，它与其他苯二氮䓬类药物一样具有镇静和抗焦虑作用。
该药物在动物体内具有食欲特性。[3][4]该药物增加进食量的机制尚不清楚，并且一直在进行研究中。[5]已发现依法西泮能够抑制胃酸的分泌。[6]
合成
[编辑]
二苯甲酮衍生物(1)与掩蔽为2,5-𫫇唑烷二酮(2)的甘氨酸等效物反应，得到最终产物(3)依法西泮。
参考资料
[编辑]- ^ 美国专利第4,010,154号
- ^ Psychotropics.dk
- ^ Baile CA, McLaughlin CL. A review of the behavioral and physiological responses to elfazepam, a chemical feed intake stimulant. Journal of Animal Science. November 1979, 49 (5): 1371–95. PMID 396294. doi:10.2527/jas1979.4951371x.
- ^ Baile CA, Naylor J, McLaughlin CL, Catanzaro CA. Endotoxin-elicited fever and anorexia and elfazepam-stimulated feeding in sheep. Physiology & Behavior. August 1981, 27 (2): 271–7. PMID 7029576. S2CID 12408796. doi:10.1016/0031-9384(81)90269-9.
- ^ Keim DA, Baile CA, Bolton JR, Wangsness PJ, Della Fera MA. Abomasal function following injections of elfazepam and 9-aza-cannabinol. Pharmacology, Biochemistry, and Behavior. January 1979, 10 (1): 63–70. PMID 35793. S2CID 915512. doi:10.1016/0091-3057(79)90170-9.
- ^ Van Den Broek GW, Robertson J, Keim DA, Baile CA. Feeding and depression of abomasal secretion in sheep elicited by elfazepam and 9-aza-cannabinol. Pharmacology, Biochemistry, and Behavior. July 1979, 11 (1): 51–6. PMID 493298. S2CID 33152825. doi:10.1016/0091-3057(79)90296-x.