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赛克利嗪

维基百科,自由的百科全书
赛克利嗪
临床资料
商品名英语Drug nomenclatureMarezine, Valoid, Nausicalm, others
AHFS/Drugs.com消费者药物信息
怀孕分级
  • : A
给药途径口服IMIV
ATC码
法律规范状态
法律规范
药物动力学数据
药物代谢N-脱甲基成二苯甲基哌嗪英语norcyclizine[1]
生物半衰期20小时
识别信息
  • 1-benzhydryl-4-methyl-piperazine
CAS号82-92-8  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.001.314 编辑维基数据链接
化学信息
化学式C18H22N2
摩尔质量266.39 g·mol−1
3D模型(JSmol英语JSmol
  • CN(CC1)CCN1C(C2=CC=CC=C2)C3=CC=CC=C3
  • InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3 checkY
  • Key:UVKZSORBKUEBAZ-UHFFFAOYSA-N checkY

赛克利嗪(英语:Cyclizine)是用于治疗和预防晕车造成的恶心呕吐头晕的药物,[2]也可用于治疗全身麻醉或使用阿片类后导致的恶心。[2][3]它通过口服直肠英语Rectal administration静脉给药。[3][4]

赛克利嗪常见的副作用包括嗜睡、口干、便秘、视力问题,更严重的副作用则包括低血压尿潴留[5]一般不推荐儿童和青光眼患者使用赛克利嗪。[2][6]赛克利嗪看起来对孕妇安全,但这尚未得到充分研究。[7]它属于抗胆碱剂抗组织胺药[3][6]

赛克利嗪于1947年被发现。[8]它是世界卫生组织基本药物[9]在美国是非处方药[6]

参考资料

[编辑]
  1. ^ DrugBank: Cyclizine. Pharmacology: metabolism. DrugBank Database. [5 January 2016]. (原始内容存档于30 January 2016). 
  2. ^ 2.0 2.1 2.2 Cyclizine 50mg Tablets - Summary of Product Characteristics (SPC) - (eMC). www.medicines.org.uk. 27 March 2015 [13 December 2016]. (原始内容存档于20 December 2016). 
  3. ^ 3.0 3.1 3.2 Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. Elsevier Health Sciences. 2015: 218. ISBN 9781455749898. (原始内容存档于2016-12-20). 
  4. ^ World Health Organization. World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 
  5. ^ Cyclizine Side Effects in Detail - Drugs.com. www.drugs.com. [13 December 2016]. (原始内容存档于21 December 2016). 
  6. ^ 6.0 6.1 6.2 Cyclizine: Indications, Side Effects, Warnings - Drugs.com. www.drugs.com. [13 December 2016]. (原始内容存档于21 December 2016). 
  7. ^ Cyclizine Use During Pregnancy | Drugs.com. www.drugs.com. [13 December 2016]. (原始内容存档于21 December 2016). 
  8. ^ Williams P. The story of the Wellcome Trust : unlocking Sir Henry's legacy to medical research. Hindringham: JJG. 2010: 14. ISBN 9781899163922. (原始内容存档于2016-12-20). 
  9. ^ World Health Organization. World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. hdl:10665/345533可免费查阅. WHO/MHP/HPS/EML/2021.02. 

外部链接

[编辑]
  • Cyclizine. Drug Information Portal. U.S. National Library of Medicine. [2023-10-22]. (原始内容存档于2022-10-27).