非諾特羅
外觀
臨床資料 | |
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AHFS/Drugs.com | Micromedex詳細消費者藥物信息 |
給藥途徑 | Inhalation (MDI) |
ATC碼 | |
法律規範狀態 | |
法律規範 |
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藥物動力學數據 | |
生物半衰期 | 6.5小時左右 [1][2][3][4] |
識別資訊 | |
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CAS號 | 13392-18-2 |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.205.960 |
化學資訊 | |
化學式 | C17H21NO4 |
摩爾質量 | 303.35 g/mol |
3D模型(JSmol) | |
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非諾特羅(Fenoterol) 是一種用來擴張呼吸道的β2腎上腺素受體激動藥。非諾特羅 屬於擬交感神經藥 β2 刺激劑和氣喘藥。
非諾特羅 由寶靈家殷格翰製造和銷售,商品名稱為:Berotec N (備勞喘)。製造商有時也會把非諾特羅與ipratropium混和後銷售,商品名稱為 Berodual N (備喘全)。
醫學用途
[編輯]非諾特羅 是短效的 β2刺激劑。當非諾特羅使用超過建議的醫療用劑量(每日最多只能吸入八劑、每劑量需間隔至少五分鐘,若氣喘狀況沒好轉,則再吸入第二劑[5])時,也會成為β1 受體刺激劑。
使用者可以於運動前吸入一劑,預防稍後因運動所誘發的氣喘(氣管痙攣)。[6]
副作用
[編輯]已知曾有患者在急性氣喘發作時吸入了高達80劑的非諾特羅,最終因而死亡。當患者發現非諾特羅已經無法緩解氣喘時,應當停止吸入非諾特羅,並盡快就醫。[7][8]
參見
[編輯]文獻來源
[編輯]- ^ Fenoterol Hydrobromide Drug Information, Professional. Drugs.com. 1996-01-01 [2018-06-11]. (原始內容存檔於2019-08-25).
- ^ Fenoterol - Drug Monograph. DrugInfoSys.com. 2016-10-27 [2018-06-11]. (原始內容存檔於2020-11-27).
- ^ Berotec Inhalation Solution (Fenoterol HBr). RxMed.com. [2018-06-11]. (原始內容存檔於2021-04-20).
- ^ Svedmyr, Nils. Fenoterol: A Beta2-adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy (Wiley). 1985-05-06, 5 (3): 109–126. ISSN 0277-0008. doi:10.1002/j.1875-9114.1985.tb03409.x.
- ^ Berotec N/Concise Prescribing Info/Full Prescribing info. 2018-02-28 [2018-02-28]. (原始內容存檔於2020-11-23).
Dosage / Direction for Use:
Acute Asthma Episodes: 1 puff is sufficient for prompt symptom relief in most cases, if breathing has not noticeably improved after 5 minutes, a second dose may be taken, up to a maximum of 8 puffs per day. If an attack has not been relieved by 2 puffs, further puffs may be required. In this situation, patients should consult the doctor or the nearest hospital immediately. (See Precautions).
Prophylaxis of Exercise Induced Asthma: 1-2 puffs prior to exercise, up to a maximum of 8 puffs per day.
Bronchial Asthma and Other Conditions with Reversible Airways Narrowing: If repeated dosing is required, 1-2 puffs for each administration, up to a maximum of 8 puffs per day. - ^ Management of acute exacerbations of asthma in adults. UpToDate. [2018-06-25]. (原始內容存檔於2018-06-25).
- ^ Beasley R, Pearce N, Crane J, Burgess C. Withdrawal of 非诺特罗 and the end of the New Zealand asthma mortality epidemic. International Archives of Allergy and Immunology. 1995, 107 (1-3): 325–7. PMID 7613161. doi:10.1159/000237016.
- ^ Spitzer WO, Suissa S, Ernst P, et al. The use of beta-agonists and the risk of death and near death from asthma. The New England Journal of Medicine. February 1992, 326 (8): 501–6. PMID 1346340. doi:10.1056/NEJM199202203260801.