非诺特罗
外观
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临床资料 | |
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AHFS/Drugs.com | Micromedex详细消费者药物信息 |
给药途径 | Inhalation (MDI) |
ATC码 | |
法律规范状态 | |
法律规范 |
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药物动力学数据 | |
生物半衰期 | 6.5小时左右 [1][2][3][4] |
识别信息 | |
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CAS号 | 13392-18-2 ![]() |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
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KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.205.960 |
化学信息 | |
化学式 | C17H21NO4 |
摩尔质量 | 303.35 g/mol |
3D模型(JSmol) | |
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非诺特罗(Fenoterol) 是一种用来扩张呼吸道的β2肾上腺素受体激动药。非诺特罗 属于拟交感神经药 β2 刺激剂和气喘药。
非诺特罗 由勃林格殷格翰制造和销售,商品名称为:Berotec N (备劳喘)。制造商有时也会把非诺特罗与ipratropium混和后销售,商品名称为 Berodual N (备喘全)。
医学用途
[编辑]非诺特罗 是短效的 β2刺激剂。当非诺特罗使用超过建议的医疗用剂量(每日最多只能吸入八剂、每剂量需间隔至少五分钟,若气喘状况没好转,则再吸入第二剂[5])时,也会成为β1 受体刺激剂。
使用者可以于运动前吸入一剂,预防稍后因运动所诱发的气喘(气管痉挛)。[6]
副作用
[编辑]已知曾有患者在急性气喘发作时吸入了高达80剂的非诺特罗,最终因而死亡。当患者发现非诺特罗已经无法缓解气喘时,应当停止吸入非诺特罗,并尽快就医。[7][8]
![](http://upload.wikimedia.org/wikipedia/commons/thumb/8/8b/Berotec.jpg/220px-Berotec.jpg)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/d/db/Berotec_in_Chinese.jpg/220px-Berotec_in_Chinese.jpg)
参见
[编辑]文献来源
[编辑]- ^ Fenoterol Hydrobromide Drug Information, Professional. Drugs.com. 1996-01-01 [2018-06-11]. (原始内容存档于2019-08-25).
- ^ Fenoterol - Drug Monograph. DrugInfoSys.com. 2016-10-27 [2018-06-11]. (原始内容存档于2020-11-27).
- ^ Berotec Inhalation Solution (Fenoterol HBr). RxMed.com. [2018-06-11]. (原始内容存档于2021-04-20).
- ^ Svedmyr, Nils. Fenoterol: A Beta2-adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy (Wiley). 1985-05-06, 5 (3): 109–126. ISSN 0277-0008. doi:10.1002/j.1875-9114.1985.tb03409.x.
- ^ Berotec N/Concise Prescribing Info/Full Prescribing info. 2018-02-28 [2018-02-28]. (原始内容存档于2020-11-23).
Dosage / Direction for Use:
Acute Asthma Episodes: 1 puff is sufficient for prompt symptom relief in most cases, if breathing has not noticeably improved after 5 minutes, a second dose may be taken, up to a maximum of 8 puffs per day. If an attack has not been relieved by 2 puffs, further puffs may be required. In this situation, patients should consult the doctor or the nearest hospital immediately. (See Precautions).
Prophylaxis of Exercise Induced Asthma: 1-2 puffs prior to exercise, up to a maximum of 8 puffs per day.
Bronchial Asthma and Other Conditions with Reversible Airways Narrowing: If repeated dosing is required, 1-2 puffs for each administration, up to a maximum of 8 puffs per day. - ^ Management of acute exacerbations of asthma in adults. UpToDate. [2018-06-25]. (原始内容存档于2018-06-25).
- ^ Beasley R, Pearce N, Crane J, Burgess C. Withdrawal of 非诺特罗 and the end of the New Zealand asthma mortality epidemic. International Archives of Allergy and Immunology. 1995, 107 (1-3): 325–7. PMID 7613161. doi:10.1159/000237016.
- ^ Spitzer WO, Suissa S, Ernst P, et al. The use of beta-agonists and the risk of death and near death from asthma. The New England Journal of Medicine. February 1992, 326 (8): 501–6. PMID 1346340. doi:10.1056/NEJM199202203260801.
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