甘露庚酮糖
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| D-Mannoheptulose | |
|---|---|
| |
| IUPAC名 D-Manno-hept-2-ulose | |
| 识别 | |
| CAS号 | 3615-44-9 
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| PubChem | 12600 |
| ChemSpider | 12080 |
| SMILES |
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| InChI |
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| 性质 | |
| 化学式 | C7H14O7 |
| 摩尔质量 | 210.18 g·mol−1 |
| 密度 | 1.7 g cm-3 |
| 若非注明，所有数据均出自一般条件（25 ℃，100 kPa）下。 | |
甘露庚酮糖（英語：Mannoheptulose）是一种庚糖，即有七个碳原子的单糖。它是己糖激酶的抑制剂，通过竞争性地与己糖激酶结合来阻断葡萄糖的磷酸化。结果是葡萄糖的降解被抑制。D-甘露庚酮糖最早在鳄梨中发现[1]。
有研究指出，甘露庚酮糖會抑制胰島素分泌[2]。 This inhibition occurs because when mannoheptulose is present the glycolysis is inhibited (because there is no production of glucose-6-P) therefore no increase in ATP concentration which is required to close the KATP channel in the beta cells of the pancreas causing a diminution of calcium entry and insulin secretion.
参考文献[编辑]
- ^ Dai, Nir; Schaffer, Arthur; Petreikov, Marina; Shahak, Yosepha; Giller, Yuri; Ratner, Kira; Levine, Alex; Granot, David. Overexpression of Arabidopsis Hexokinase in Tomato Plants Inhibits Growth, Reduces Photosynthesis, and Induces Rapid Senescence. The Plant Cell. 1999-07, 11 (7): 1253–1266 [2021-11-10]. ISSN 1040-4651. PMC 144264
. PMID 10402427. doi:10.1105/tpc.11.7.1253. （原始内容存档于2022-01-11） （英语）.
- ^ Lucke, C.; Kagan, A.; Adelman, N.; Glick, S. M. Effect of 2-Deoxy-D-Glucose and Mannoheptulose on the Insulin Response to Amino Acids in Rabbits. Diabetes. 1972-01-01, 21 (1): 1–5. ISSN 0012-1797. doi:10.2337/diab.21.1.1 （英语）.
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