甘露庚酮糖
| D-Mannoheptulose | |
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| IUPAC名 D-Manno-hept-2-ulose |
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| 识别 | |
| CAS号 | 3615-44-9 |
| PubChem | 12600 |
| ChemSpider | 12080 |
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| InChI |
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| 性质 | |
| 化学式 | C7H14O7 |
| 摩尔质量 | 210.18 g·mol−1 |
| 密度 | 1.7 g cm-3 |
| 若非注明，所有数据均出自一般条件（25 ℃，100 kPa）下。 | |
甘露庚酮糖（英语：Mannoheptulose）是一种庚糖，即有七个碳原子的单糖。它是己糖激酶的抑制剂，通过竞争性地与己糖激酶结合来阻断葡萄糖的磷酸化。结果是葡萄糖的降解被抑制。D-甘露庚酮糖最早在鳄梨中发现[1]。
有研究指出，甘露庚酮糖會抑制胰島素分泌[2]。 This inhibition occurs because when mannoheptulose is present the glycolysis is inhibited (because there is no production of glucose-6-P) therefore no increase in ATP concentration which is required to close the KATP channel in the beta cells of the pancreas causing a diminution of calcium entry and insulin secretion.
参考文献[编辑]
- ^ Dai, N; Schaffer, A; Petreikov, M; Shahak, Y; Giller, Y; Ratner, K; Levine, A; Granot, D. Overexpression of Arabidopsis hexokinase in tomato plants inhibits growth, reduces photosynthesis, and induces rapid senescence. The Plant cell. 1999, 11 (7): 1253–66. PMC 144264. PMID 10402427.
- ^ Lucke, Christoph; Kagan, Avir; Adelman, Neil; Glick, Seymour. Effect of 2-Deoxy-D-Glucose and Mannoheptulose on the Insulin Response to Amino Acids in Rabbits. Diabetes. 1972, 21 (1).
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