孕烷醇酮
| 孕烷醇酮 | |
|---|---|
| |
| IUPAC名 1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone | |
| 別名 | Eltanolone; 5β-Pregnan-3α-ol-20-one; 3α-Hydroxy-5β-pregnan-20-one; 3α,5β-Tetrahydroprogesterone; 3α,5β-THP; 3α-Hydroxy-5β-tetrahydroprogesterone |
| 識別 | |
| CAS號 | 128-20-1 |
| PubChem | 31402 |
| ChemSpider | 29132 |
| SMILES |
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| InChI |
|
| InChIKey | AURFZBICLPNKBZ-YZRLXODZBF |
| ChEBI | 1712 |
| 性質 | |
| 化學式 | C21H34O2 |
| 摩爾質量 | 318.49 g·mol−1 |
| 藥理學 | |
| 給藥途徑 | Intravenous injection[1] |
| 藥代動力學： | |
| 0.9–3.5 hours[1][2][3] | |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
孕烷醇酮（英語：Pregnanolone，也名為3α,5β-孕烷醇酮）也被稱為乙他諾隆（英語：eltanolone）是一種內源性的抑制性神經甾體，在體內由孕酮合成而來[4]，和其異構體別孕烷醇酮有着類似的性質[4]。
參考文獻
[編輯]- ^ 1.0 1.1 Carl P, Høgskilde S, Lang-Jensen T, et al. Pharmacokinetics and pharmacodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in humans. Acta Anaesthesiol Scand. October 1994, 38 (7): 734–41. PMID 7839787. doi:10.1111/j.1399-6576.1994.tb03987.x.
- ^ Gray HS, Holt BL, Whitaker DK, Eadsforth P. Preliminary study of a pregnanolone emulsion (Kabi 2213) for i.v. induction of general anaesthesia. Br J Anaesth. March 1992, 68 (3): 272–6. PMID 1547051. doi:10.1093/bja/68.3.272.
- ^ Carl P, Høgskilde S, Nielsen JW, Sørensen MB, Lindholm M, Karlen B, Bäckstrøm T. Pregnanolone emulsion. A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent. Anaesthesia. March 1990, 45 (3): 189–97. PMID 2334030. doi:10.1111/j.1365-2044.1990.tb14683.x.
- ^ 4.0 4.1 Reddy DS. Pharmacology of endogenous neuroactive steroids. Crit Rev Neurobiol. 2003, 15 (3–4): 197–234. PMID 15248811. doi:10.1615/critrevneurobiol.v15.i34.20.