玉米赤霉醇

**玉米赤霉醇**
臨床資料
商品名（英语：Drug nomenclature）	Frideron, Ralabol, Ralgro, Ralone, Zerano
其他名稱	Zearanol; α-Zearalanol; Zearalanol; MK-188; P-1496
给药途径	By mouth
藥物類別（英语：Drug class）	Nonsteroidal estrogen
识别信息
	IUPAC命名法 (3S,7R)-7,14,16-trihydroxy-3-methyl-3,4,5,6,7,8,9,10,11,12-decahydro-1H-2-benzoxacyclotetradecin-1-one; ;
CAS号	26538-44-3
PubChem CID	2999413;
ChemSpider	2271133 ;
UNII	76LO2L2V39;
ChEMBL	ChEMBL371463 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID4022315 ;
ECHA InfoCard	100.043.411
化学信息
化学式	C18H26O5
摩尔质量	322.40 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C[C@H]1CCC[C@@H](CCCCCC2=C(C(=CC(=C2)O)O)C(=O)O1)O;
	InChI InChI=1S/C18H26O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,14,19-21H,2-9H2,1H3/t12-,14+/m0/s1 ; Key:DWTTZBARDOXEAM-GXTWGEPZSA-N ;

玉米赤霉醇（英文名Zeranol），又称右环十四酮酚，折仑诺，α-玉米赤霉醇，是一种在镰刀菌属（Fusarium genus）中发现的属于间羟基苯甲酸内酯的合成非甾体雌激素，主要用作兽药中的合成代谢剂。^[1]^[2]^[3]

玉米赤霉醇在美国被批准以商标名Ralgro（Merck Animal Health）用作家畜（包括肉牛）的生长促进剂。在加拿大仅被批准用于肉牛。在欧盟其申请未获批准使用。

虽然玉米赤霉醇可能会增加乳腺癌癌细胞增殖，^[4]一些学者认为，使用含有玉米赤霉醇牛制品，这种膳食暴露是微不足道。^[5]研究发现玉米赤霉醇是真菌感染作物中的污染物。它作为雌激素的效力是相关化合物玉米赤霉烯酮的3至4倍。^[6]

参见[编辑]

参考文献[编辑]

^ J.,, Elks,; Robin),, Ganellin, C. R. (C. Dictionary of drugs : chemical data, structures, and bibliographies. Dordrecht https://www.worldcat.org/oclc/898564124. ISBN 9781475720853. OCLC 898564124. 缺少或|title=为空 (帮助)
^ Apotheker-Verein., Schweizerischer. Index nominum, international drug directory = internationales Arzneistoff-und Arzneimittelverzeichnis = répertoire international des substances médicamenteuses et spécialités pharmaceutiques. 17th ed. Stuttgart: Medpharm Scientific Publishers https://www.worldcat.org/oclc/43715000. 2000. ISBN 3887630750. OCLC 43715000. 缺少或|title=为空 (帮助)
^ M., Morton, Ian K. Concise Dictionary of Pharmacological Agents : Properties and Synonyms. Dordrecht: Springer Netherlands https://www.worldcat.org/oclc/851393222. 1999. ISBN 9789401144391. OCLC 851393222. 缺少或|title=为空 (帮助)
^ Xu, Pingping; Ye, Weiping; Jen, Robert; Lin, Shu-Hong; Kuo, Chieh-Ti; Lin, Young C. Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. Anticancer Research. 2009-11, 29 (11): 4621–4628 [2018-08-17]. ISSN 1791-7530. PMID 20032412. （原始内容存档于2019-08-19）.
^ Lindsay, D. G. Zeranol--a 'nature-identical' oestrogen?. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association. 1985-8, 23 (8): 767–774 [2018-08-17]. ISSN 0278-6915. PMID 2931335. （原始内容存档于2019-08-13）. 请检查|date=中的日期值 (帮助)
^ Mirocha, C J; Schauerhamer, B; Christensen, C M; Niku-Paavola, M L; Nummi, M. Incidence of zearalenol (Fusarium mycotoxin) in animal feed.. Applied and Environmental Microbiology. 1979-10, 38 (4): 749–750 [2018-08-17]. ISSN 0099-2240. PMC 243572 . PMID 161492. （原始内容存档于2021-09-22）.

Template:Xenoestrogens

[1] J.,, Elks,; Robin),, Ganellin, C. R. (C. Dictionary of drugs : chemical data, structures, and bibliographies. Dordrecht https://www.worldcat.org/oclc/898564124. ISBN 9781475720853. OCLC 898564124. 缺少或|title=为空 (帮助)

[2] Apotheker-Verein., Schweizerischer. Index nominum, international drug directory = internationales Arzneistoff-und Arzneimittelverzeichnis = répertoire international des substances médicamenteuses et spécialités pharmaceutiques. 17th ed. Stuttgart: Medpharm Scientific Publishers https://www.worldcat.org/oclc/43715000. 2000. ISBN 3887630750. OCLC 43715000. 缺少或|title=为空 (帮助)

[3] M., Morton, Ian K. Concise Dictionary of Pharmacological Agents : Properties and Synonyms. Dordrecht: Springer Netherlands https://www.worldcat.org/oclc/851393222. 1999. ISBN 9789401144391. OCLC 851393222. 缺少或|title=为空 (帮助)

[4] Xu, Pingping; Ye, Weiping; Jen, Robert; Lin, Shu-Hong; Kuo, Chieh-Ti; Lin, Young C. Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. Anticancer Research. 2009-11, 29 (11): 4621–4628 [2018-08-17]. ISSN 1791-7530. PMID 20032412. （原始内容存档于2019-08-19）.

[5] Lindsay, D. G. Zeranol--a 'nature-identical' oestrogen?. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association. 1985-8, 23 (8): 767–774 [2018-08-17]. ISSN 0278-6915. PMID 2931335. （原始内容存档于2019-08-13）. 请检查|date=中的日期值 (帮助)

[6] Mirocha, C J; Schauerhamer, B; Christensen, C M; Niku-Paavola, M L; Nummi, M. Incidence of zearalenol (Fusarium mycotoxin) in animal feed.. Applied and Environmental Microbiology. 1979-10, 38 (4): 749–750 [2018-08-17]. ISSN 0099-2240. PMC 243572 . PMID 161492. （原始内容存档于2021-09-22）.

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