水杨酸钠

水杨酸钠
英文名	Sodium salicylate
别名	邻羟基苯甲酸钠；2-羟基苯甲酸单钠盐；柳酸钠；杨酸钠；2-羟基苯甲酸钠;
识别
CAS号	54-21-7
PubChem	16760658
ChemSpider	5689
SMILES	[Na+].O=C([O-])c1ccccc1O;
InChI	1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m;
EINECS	200-198-0
RTECS	VO5075000
DrugBank	DB01398
KEGG	D00566
性质
化学式	C7H5NaO3
摩尔质量	160.11 g/mol g·mol⁻¹
外观	白色晶体
熔点	200 °C
溶解性（水）	~ 660 g/l at 20 °C
危险性
警示术语	R：R22, R36/37/38
安全术语	S：S24/25, S26, S36/37/39
主要危害	有害
NFPA 704	1 1 0
自燃温度	> 250 °C
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

水楊酸鈉（化學式：C₇H₅NaO₃或 NaC₆H₄(OH)CO₂）是水楊酸的鈉鹽，可以通過苯酚和二氧化碳在較高的溫度和壓強下製取。歷史上，水楊酸鈉則是通過升華水楊酸與過量的碳酸氫鈉發生反應，再用加熱迴流的方式來獲得。^[1]

属性[编辑]

水杨酸钠是水杨酸中的一员，然而，儿童和青少年在流感或水痘等病毒引起的疾病之后使用水杨酸，可能会诱发雷氏症候群，因此不建议19岁以下发热的病人使用含有水杨酸的产品和药物。

用途[编辑]

水杨酸钠在医学上主要当作镇痛药和退热剂，同时它也是一种非甾体抗炎药，并能诱使癌细胞凋亡^[2]^[3]^[4]或坏死^[5]，在病人对阿司匹林过敏时，可以作为其替代药物使用。它还是常见的检测辐射和电子的真空紫外荧光粉。^[6]

注释[编辑]

^ Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009
^ Klampfer, Lidija; Jörg Cammenga, Hans-Georg Wisniewski, Stephen D. Nimer. Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines. Blood. 1999-04-01, 93 (7): 2386–94 [2011-02-21]. PMID 10090950. （原始内容存档于2010-04-04）.
^ Rae, Colin; Susana Langa, Steven J. Tucker, David J. MacEwan. Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis. Proceedings of the National Academy of Sciences of the USA. 2007-07-31, 104 (31): 12790–5 [2011-02-21]. PMC 1937545 . PMID 17646662. doi:10.1073/pnas.0701437104. （原始内容存档于2015-09-24）.
^ Stark, Lesley A.; et al. Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis. 2007-05, 28 (5): 968–76 [2011-02-21]. PMID 17132819. doi:10.1093/carcin/bgl220. （原始内容存档于2012-07-07）.
^ Schwenger, Paul; Edward Y. Skolnik, Jan Vilcek. Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate. The Journal of Biological Chemistry. 1996-04-05, 271 (14): 8089–94 [2011-02-21]. PMID 8626494. doi:10.1074/jbc.271.14.8089.
^ Samson, James. Vacuum Ultraviolet Spectroscopy (PDF). Pied Publications. [July 26, 2012]. （原始内容 (PDF)存档于2014年8月1日）.

[1] Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009

[2] Klampfer, Lidija; Jörg Cammenga, Hans-Georg Wisniewski, Stephen D. Nimer. Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines. Blood. 1999-04-01, 93 (7): 2386–94 [2011-02-21]. PMID 10090950. （原始内容存档于2010-04-04）.

[3] Rae, Colin; Susana Langa, Steven J. Tucker, David J. MacEwan. Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis. Proceedings of the National Academy of Sciences of the USA. 2007-07-31, 104 (31): 12790–5 [2011-02-21]. PMC 1937545 . PMID 17646662. doi:10.1073/pnas.0701437104. （原始内容存档于2015-09-24）.

[4] Stark, Lesley A.; et al. Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis. 2007-05, 28 (5): 968–76 [2011-02-21]. PMID 17132819. doi:10.1093/carcin/bgl220. （原始内容存档于2012-07-07）.

[5] Schwenger, Paul; Edward Y. Skolnik, Jan Vilcek. Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate. The Journal of Biological Chemistry. 1996-04-05, 271 (14): 8089–94 [2011-02-21]. PMID 8626494. doi:10.1074/jbc.271.14.8089.

[6] Samson, James. Vacuum Ultraviolet Spectroscopy (PDF). Pied Publications. [July 26, 2012]. （原始内容 (PDF)存档于2014年8月1日）.

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