甘草素

甘草素
	IUPAC名; (2S)-4′,7-二羥基黃酮-4-酮
	系統名; (2S)-7-羥基-2-(4-羥基苯基)-2,3-二氫-4H-1-苯並吡喃-4-酮
識別
CAS號	578-86-9
PubChem	114829
ChemSpider	102790
SMILES	O=C2c3c(O[C@H](c1ccc(O)cc1)C2)cc(O)cc3;
InChI	1/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1;
InChIKey	FURUXTVZLHCCNA-AWEZNQCLBC
ChEBI	28777
KEGG	C09762
性質
化學式	C15H12O4
摩爾質量	256.25 g·mol−1
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

甘草素（英語：Liquiritigenin）或譯為甘草醇，是一種黃烷酮，從『甘草』（學名：Glycyrrhiza uralensis）中分離出來，在甘草屬植物中廣泛存在，包括『光果甘草』（學名：Glycyrrhiza glabra）。^[1]它是一種雌激素化合物，作為雌激素受體（ER）的ERβ亞型的選擇性激動劑，儘管在足夠高的濃度下據報導，也能作為ERα的部分激動劑。^[2] 它也具有利膽作用。^[1]

甘草素，NADPH：氧氧化還原酶（羥基化，芳基遷移）是一種酶，使用甘草素，O₂，NADPH和H⁺產生2,7,4'-三羥基異黃酮，H₂O和NADP⁺。

參見[編輯]

參考[編輯]

^ ^1.0 ^1.1 Kim, YW; Kang, HE; Lee, MG; Hwang, SJ; Kim, SC; Lee, CH; Kim, SG. Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2009, 296 (2): G372–81. PMID 19074639. doi:10.1152/ajpgi.90524.2008.
^ Mersereau, Jennifer E.; Levy, Nitzan; Staub, Richard E.; Baggett, Scott; Zogric, Tetjana; Chow, Sylvia; Ricke, William A.; Tagliaferri, Mary; et al. Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist. Molecular and Cellular Endocrinology. 2008, 283 (1–2): 49–57. PMC 2277338 . PMID 18177995. doi:10.1016/j.mce.2007.11.020.

這是一篇有關芳香化合物的小作品。你可以透過編輯或修訂擴充其內容。

[Kim-1] 1.0 ^1.1 Kim, YW; Kang, HE; Lee, MG; Hwang, SJ; Kim, SC; Lee, CH; Kim, SG. Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2009, 296 (2): G372–81. PMID 19074639. doi:10.1152/ajpgi.90524.2008.

[2] Mersereau, Jennifer E.; Levy, Nitzan; Staub, Richard E.; Baggett, Scott; Zogric, Tetjana; Chow, Sylvia; Ricke, William A.; Tagliaferri, Mary; et al. Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist. Molecular and Cellular Endocrinology. 2008, 283 (1–2): 49–57. PMC 2277338 . PMID 18177995. doi:10.1016/j.mce.2007.11.020.

[1]

[2]