尼氟滅酸

**尼氟滅酸**
臨床資料
AHFS/Drugs.com	国际药品名称
ATC碼	M01AX02 (WHO) M02AA17;
藥物動力學數據
生物半衰期	2.5 hr
识别信息
	IUPAC命名法 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid; ;
CAS号	4394-00-7
PubChem CID	4488;
IUPHAR/BPS	2439;
ChemSpider	4333 ;
UNII	4U5MP5IUD8;
KEGG	D08275 ;
ChEMBL	ChEMBL63323 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID1023368 ;
ECHA InfoCard	100.022.289
化学信息
化学式	C13H9F3N2O2
摩尔质量	282.22 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
熔点	204 °C（399 °F）
	SMILES C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F;
	InChI InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) ; Key:JZFPYUNJRRFVQU-UHFFFAOYSA-N ;

尼氟灭酸（英語：Niflumic acid；别名尼氟酸、氟尼酸）是一种治疗关节和肌肉疼痛的药物。它被归类为环氧合酶-2的抑制剂。在实验生物学中，尼氟灭酸也应用于抑制氯离子通道（英语：chloride channel）。^[2]还有报道称，尼氟灭酸能够作用于GABA-A^[3]及NMDA受体通道，^[4]并能阻滞T-型钙离子通道。^[5]

参考资料[编辑]

^ Half life. Drug Bank. [15 July 2011]. （原始内容存档于2012-02-03）.
^ Knauf PA, Mann NA. Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system. The Journal of General Physiology. May 1984, 83 (5): 703–25. PMC 2215658 . PMID 6736917. doi:10.1085/jgp.83.5.703.
^ Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER. Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug. Molecular Pharmacology. September 2003, 64 (3): 753–63. PMID 12920213. doi:10.1124/mol.64.3.753.
^ Lerma J, Martín del Río R. Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation. Molecular Pharmacology. February 1992, 41 (2): 217–22. PMID 1371581.
^ Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A. Niflumic acid blocks native and recombinant T-type channels. Journal of Cellular Physiology. June 2012, 227 (6): 2542–55. PMC 4146346 . PMID 21898399. doi:10.1002/jcp.22992.

[1] Half life. Drug Bank. [15 July 2011]. （原始内容存档于2012-02-03）.

[2] Knauf PA, Mann NA. Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system. The Journal of General Physiology. May 1984, 83 (5): 703–25. PMC 2215658 . PMID 6736917. doi:10.1085/jgp.83.5.703.

[3] Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER. Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug. Molecular Pharmacology. September 2003, 64 (3): 753–63. PMID 12920213. doi:10.1124/mol.64.3.753.

[4] Lerma J, Martín del Río R. Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation. Molecular Pharmacology. February 1992, 41 (2): 217–22. PMID 1371581.

[5] Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A. Niflumic acid blocks native and recombinant T-type channels. Journal of Cellular Physiology. June 2012, 227 (6): 2542–55. PMC 4146346 . PMID 21898399. doi:10.1002/jcp.22992.

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